Synthesis, Characterization, Biological Evaluation and Anti Corrosion Activity of Some Heterocyclic Compounds Oxazepine Derivatives from Schiff Bases
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چکیده
A series of Schiff base and their derivative (oxazepine) have been synthesized. 1, 4-Bis (3-aminopropyl)piperazine was condensed with various aromatic aldehyde in ethanol in the presence of acetic acid as catalyst to yield the Schiff bases. These Schiff’s bases on treatment with phthalic anhydride gave substituted oxazepine. The structure of synthesized Schiff bases has been established on the basis of their spectral (FT-IR, Mass, 1H, 13C-NMR, elemental analysis) data. The purity of the compounds was confirmed by TLC. The biological activities of some prepared compounds were also studied against four different kinds of bacteria. These compounds were tested to determine their ability to inhibit corrosion of mild steel in 1 mol.l-1 H2SO4. adsorbed species protect the metal from the aggressive medium, which causes decomposition of the metal, but also on the chemical structure of the inhibitor [13-16]. In this work, the inhibiting action of Schiff bases and their derivative on the corrosion steel in 1M H2SO4 solution has been investigated. The electro chemical techniques such as polarization measurements were used in this study. Differences in behavior of inhibitors were explained based on structural properties of investigated inhibitors. Material and Methods General procedures Melting points were determined in open glass capillaries on agallenkamp apparatus and are uncorrected. TLC was performed to assess the reactions and the purity of the products using glass plates coated with silica gel of 0.25 mm thickness using mixture of petroleum ether/ethyl acetate (7:3; 6:4; 5:5 by V/V) as mobile phase Spots were visualized using iodine chamber and UV light chamber. IR spectra were recorded in KBr (pellet forms) on aNicoletAvatar-330 FT-IR spectrophotometer and note worthy absorption values (cm-1) alone are listed.1H and 13C NMR Spectra were recorded at 400 MHZ Bruker AMX using CDCl3 as solvent. The ESI+ve MS spectra were recorded on a Bruker Daltonics LC-MS Spectrometer. Satisfactory microanalysis was obtained on Carlo Erba 1106 CHN analyzer. Potantiostat – galvanostat from Amel instruments where used for corrosion activity. Citation: Hamak KF, Eissa HH (2013) Synthesis, Characterization, Biological Evaluation and Anti Corrosion Activity of Some Heterocyclic Compounds Oxazepine Derivatives from Schiff Bases. Organic Chem Curr Res 2: 121. doi:10.4172/2161-0401.1000121
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